No, but it’s one of the versions that works with game version 1.6.640. The most accurate current version is 2.2.6.
Never download SKSE from random file-sharing sites, YouTube descriptions, or forums offering a "special 16640 link." Malware disguised as SKSE is common. Always verify the game version and match it with the official SKSE archive. skse 16640 link
The only safe and official place to download SKSE is the skse.silverlock.org website or the official Nexus Mods page. No, but it’s one of the versions that
: If this refers to a technical code (e.g., SKSE 16640 as a product/specification): skse 16640 link
For Skyrim Special Edition (runtime 1.6.640), the compatible version of SKSE64 is build 2.2.1