Dean's struggle with the Mark of Cain eventually unleashed "The Darkness" (Amara), the sister of God, forcing an uneasy alliance with Lucifer and Crowley. Season 12: Family Reunited and New Blood (2016–2017)

The show's first season premiered in 2005 and consisted of 16 episodes. The pilot episode, "Pilot," introduced audiences to the Winchester brothers, who are on a mission to find their father, John Winchester (Jeffrey Dean Morgan), who has gone missing while hunting a supernatural creature. Throughout the season, the brothers face various challenges, including battling ghosts, demons, and other creatures.

Originally envisioned as a five-year story arc by creator Eric Kripke, this era focused on the brothers searching for their father and eventually averting the Biblical Apocalypse. It remains the gold standard for many fans, culminating in the masterpiece finale "Swan Song."

Assuming you are looking for a retrospective on the legendary 15-season run of Sam and Dean Winchester, here is a deep dive into the legacy of the show that defined a generation of genre TV.

Following Kripke's departure as showrunner, the series expanded into new mythologies involving Purgatory, the Leviathans, and the "Mark of Cain". The Late CW Era (Seasons 11–12):

You can find these box sets at major retailers and resale platforms: : Often stocks both the S1-12 collection and the Supernatural: The Complete Series (Seasons 1-15) on DVD or Blu-ray.